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The risk of hypoglycaemia would be more relevant if either agent were used alongside insulin or a sulfonylurea, or in the context of severe caloric restriction

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9 Common Questions." FDA: "FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss," "Label: Foundayo (Orforglipron)." National Association of Insurance Commissioners: "Does Insurance Cover Prescription Weight Loss Injectables?" University of Chicago Medicine: "Research shows GLP-1 receptor agonist drugs are effective but come with complex concerns." Massachusetts General Hospital: "Preserving Lean Body Mass in Patients Taking GLP-1 for Weight Loss." UT Southwestern Medical Center: "Weight-loss medications: The 5 most-asked questions." University of Kansas Health System: "Surprises and Concerns About GLP-1 Medications." Brown University Health: "Compounded Weight Loss Medications: What are They and What are Their Risks?" University of Missouri Health: "Thinking About Microdosing GLP-1